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Cell Culture Stainless Steel Bioreactors

The cell culture stainless steel bioreactors are designed for commercial application and industrial manufacturing with stronger performance.

Standard Stainless Steel Vessel

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  • Available from 10L to 300L, up to 70% working volume (larger volume available).

  • Batch, fed-batch, continuously-batch, semi-continuous and high-density batch systems.

  • Sterilization-In-Place (SIP), equipped with high temperature steam pipeline.

  • Standard sensor ports for precise measurement and control of temperature, pH, DO,  antifoam, feed, aeration and pressure.

  • Optional Clear-In-Place (CIP), one port for cleaning device is provided at the top of the tank.

  • Jacket vessel allows hot water and cooler to adjust the temperature.

  • Standard with mechanical stirring, special stirring shaft material and precision processing. it has ideal dynamic balance performance with proper ratio of upper and lower shaft.

  • Standard with flat or pitched-blade- impellers; other type impellers are available.

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Features of Controlling Tower

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Multiple Control Function

  • Associated control: temperature, stirring speed, pH, dissolved oxygen, defoaming, airflow, tank pressure, feed amount and other direct parameters.

  • Remote monitoring: Suitable for smartphones, tablets, laptops and PC for instant remote monitoring.

  • Step control: Users can switch directly between manual control and step control and set at least 10-step control program for temperature, agitation, PH, DO and feeding.

Smart PID control

  • Temperature, stirring speed, Ph, DO and other parameters in the tank can be controlled by subsection curve setting according to the process requirements.

  • Temperature Control: Adopt PID automatic control mode; SS316L jacket base for electric heating and cold water for cooling.

  • Dissolved oxygen control: equipped with DO electrode and shielded conductor, DO is associated with stirring motor speed, feeding, airflow, tank pressure and other parameters.

  • PH value control: Intelligent PID system control built-in control peristaltic pumps for acid-alkali adjustment, with high control precision.

  • Antifoam control: Foams are automatically detected and the peristaltic pump is controlled to add defoamer in proportion to time.

  • Feeding control: Peristaltic pump switch control (manual, automatic, and off); accumulation volume control; coupled with other parameters (DO, pH, etc).

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Upgrading Option List

Standard Type Specifications

Title
BR500-C1
BR500-C2
Controller
One console for one vessel
One console for two vessels
Display / Operation
Touch panel 10" / Touch screen
Touch panel 10" / Touch screen
Gas inlet
Air/O2/CO2/N2, four rotameters
Air/O2/CO2/N2, four rotameters
USB
1 x RS485
2 x RS485
Vessel
10L / 15L / 20L / 30L / 50L / 100L
2 x 10L / 15L / 20L / 30L / 50L / 100L
Working volume
9.8L / 13.5L / 20.3L / 25.5L / 43.5L / 99L
2 x 9.8L / 13.5L / 20.3L / 25.5L / 43.5L / 99L
Stirring speed
5 - 1000 rpm
5 - 1000 rpm
Motor power (Kw)
0.75/1/1/1/0.75/1.5
0.75/1/1/1/0.75/1.5
Pressure
0.30Mpa
0.30Mpa
Material
SS304 & SS316L stainless steel
SS304 & SS316L stainless steel
Serilization
Sterilization in place
Sterilization in place
Feeding pumps
4 peristaltic pumps
8 peristaltic pumps
Peristic pump tube ID
0.5 mm
0.8 mm
Peristic pump flow rare
0.06/revolution
0.15/revolution
Sensors
PT100, DO, foam, pH
PT100, DO, foam, pH
Temperature
Eletrical heating sleeve with bottom water to control heating / cooling
Eletrical heating sleeve with bottom water to control heating / cooling
pH control
Range: 2 - 12(±0.01),display: 0 - 14(±0.01)
Range: 2 - 12(±0.01),display: 0 - 14(±0.01)
DO control
Range: 0 - 150% (±3%), international eletrode and shielded wire detection
Range: 0 - 150% (±3%), international eletrode and shielded wire detection
Defoam control
Automatic foam detection, automatically add defoamer in proportion to time
Automatic foam detection, automatically add defoamer in proportion to time
Agitation control
Servo motor, PID control, stepless speed regulation
Servo motor, PID control, stepless speed regulation
Areation airflow
2VVM
2VVM
Areation filter
0.2μm
0.2μm
Areation
0.5SLPM, 1.0SLPM, 2.5SLPM, 5.0SLPM, 10SLPM, 25SLPM (customizable)
0.5SLPM, 1.0SLPM, 2.5SLPM, 5.0SLPM, 10SLPM, 25SLPM (customizable)
Areation flowmeter
Air calibrated, 1.2bar 20℃
Air calibrated, 1.2bar 20℃

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