Product Overview
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The BR200e Series combines compact design with advanced automation for efficient bioprocess research and development. With interchangeable vessel volumes ranging from 1 L to 15 L, the system supports both single-vessel and dual-vessel control configurations, which offers flexible scalability for microbial fermentation (BR200e-M1/M2) and cell culture (BR200e-C1/C2) applications.
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Integrated manually adjustable rotameters provide simple, durable, and cost-effective gas flow control, while variable-speed peristaltic pumps accurately deliver acid, base, antifoam, and feed solutions for stable and reliable process operation. Modular expansion options enable customized configurations to support a wide range of research and process development needs.
1 - 15 L
Vessel Volume
22"
Touchscreen
Up to 8 Vessels
Centralized Management
Key Features
Next-Generation Interface
Equipped with a 22“ high-resolution capacitive touchscreen, supporting multi-touch gestures, pinch-to-zoom, and glove operation for an intuitive user experience
Versatile Bioprocessing Platform
Supports microbial fermentation, mammalian cell culture, and algae cultivation through flexible configurations of agitation systems, illumination modules, and process control strategies
Reliable Gas & Feed Control
Gas flow is manually regulated through durable rotameters, offering a simple and economical solution. Front-mounted variable-speed peristaltic pumps deliver precise delivery of acid, base, defoamer, and feed media
Smart Modular Expansion
BR200-EM8 Module supports up to 8 peripheral devices, including sensors, balances, scales, pumps, and off-gas analyzers, providing flexible connectivity for customized bioprocess configurations
Superior Process Control
Powered by Siemens S7-1200 PLC controller with top-tier hardware components including German JUMO Pt100 RTD and Hamilton pH/DO electrodes, delivering highly stable and industrial-grade process control
Flexible Operation Modes
In addition to the touchscreen interface, the system supports operation via a keyboard, mouse, and external monitor, allowing flexible switching according to user preferences
Three Levels of Scalability Architecture
LEVEL 1
Vessel Switching
Interchangeable vessels ranging from 2 L–15 L, allowing easy changeover within a single controller
LEVEL 2
Dual-Vessel Control
The primary control unit supports connection to an additional controller via Ethernet communication, enabling centralized control and synchronized operation between two vessels
LEVEL 3
SCADA 8-Unit Cluster
Optional SCADA integration enables centralized monitoring and management of up to 8 units for parallel operation
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Smart layout by volume: All critical components are integrated into the vessel lid, enabling seamless configuration of accessories and sensors for flexible functional expansion.
Agitation Port | Maintenance-free, low-noise servo motor. Customized agitation mode, speed range, and impeller options available. |
Gas Inlet Port | Supports standard four gas inputs (Air, CO₂, N₂, O₂). Customized gas configurations available. |
Exhaust Port | Exhaust condenser minimizes moisture loss and reduces exhaust gas temperature. |
Temp. Sensor | German JUMO Pt100 RTD, 0–150°C range, ±0.2°C accuracy. Controlled by electric heating blanket and internal water circulation system. |
pH Sensor | Hamilton gel-filled pH electrode, pH 2.0–12.0 range, ±0.05 accuracy. Cascade control with acid/base pumps and CO₂ flow, etc. |
DO Sensor | Hamilton polarographic DO electrode, 0–150% range, ±3% accuracy. Cascade control with agitation, feeding, and gas flows. |
Foam Sensor | Standard foam detection electrode with automatic antifoam dosing via peristaltic pump. |
Baffle Port with Cooling Coil | Supports tap water or chilled water circulation. Optional chiller integration available. |
Feed Port | Peristaltic pump feeding, or with needle addition. |
Inoculation | Standard flame inoculation port. |
Sampling | Aseptic sampling device: sterile syringe, Luer connector, one-way valve, T-joint, and needle filter. |
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Built on a Siemens S7 1200 PLC controller, the system supports PID control, cascade strategies, recipe management, and over-limit alarms. Upgradable electronic signatures and audit trails ensure compliance with 21 CFR Part 11 and GMP standards.
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BR200e Series