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Single-use Bioreactors
 

  • SUB500 Series

  • From 50L to 2000L

SUB500 Series Single-use Bioreactors

The single-use bioreactor, derived from stainless steel bioreactor technology, simplifies operations and reduces the risk of cross-contamination in the cultivation of various cell lines.

SUB500 is a stirred-tank, disposable bioreactor for cultivating human, mammalian, and animal cells. It combines the efficiency of single-use systems with the high performance of conventional stainless steel bioreactors. The single-use design eliminates tedious cleaning, sterilization, and reducing setup times. The unique stirring system brings better gas transfer and liquid mixing, thus achieving faster production speed and a higher yield. With a wide volume range from 50L to 2000L, TheSUB500 is a perfect choice for trial, pilot-scale or industrial scale applications.

  • Built with load cell system

  • Intuitive and clear Siemens display

  • Pre-sterilized, no cleaning required

  • Modular design ensures easy scale-up

  • On-line measurement of DO and PH

  • Fully scalable from 50L to 2000L

Features

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User-friendly Operation

The intuitive color-touch screen makes it easy to set, control and monitor all the parameters. The single-use design ensures user-friendly operation and easy maintenance, and the entire bag can be easily disconnected using a sterile disconnection method.

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Easy Scale-up

The SUB500 series single-use bioreactor has a wide volume range from 50L to 2000L, providing an easy transition from lab scale to commercial scale. Its consistent performance across different volumes simplifies the scale-up process.

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Premium Quality

Each part of the single-use bioreactor is built keeping the quality in mind. The single-use bag is made from Renolit membrane and has passed multiple of compliance testing. The results show our bioreactor fully meets the culture needs of HEK293, CHO, and SF9 cells.

The single-use bag is made from RENOLIT membrane which offers excellent gas permeability and chemical stability, ensuring optimal cell growth conditions. It is suitable for mammalian and insect cell cultures, making it ideal for processes in antibody production, vaccine development, and cell and gene therapies

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  • Volume: 5L to 100L

  • Temperature Range: 8℃ to 40℃

  • Excellent gas permeability

  • Outstanding biocompatibility

  • Lightweight and flexible

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Specifications

Controller

SUB500-C-50L

 

65

50

25

0.2

 

30~200

0~10

0~5

0~5

0~5

SUB500-C-100L

131

​100

50

0.2

 

30~200

 

0~10

0~5

0~5

0~5

.

SUB500-C-250L

 

316

250

125

0.2

 

30~150

0~10

0~5

0~5

0~5

SUB500-C-500L

 

660

500

250

0.4

 

30~150

 

0~20

0~10

0~10

0~10

SUB500-C-1000L

 

1320

1000

500

0.4

 

20~110

 

0~20

0~10

0~10

0~10

±5%

0~14

0~300

Support two-point calibration and online calibration.

Vessel

Volume (L)

Nominal Working Volume (L)

Min. Working Volume (L)

Motor Power (KW)

Control

Speed Range (RPM)

Temperature Control Range (℃)

Air flow meter control range  (Overlay) (L)

Air flow meter control range (Sparger) (L)

O2 flow meter control range (L)

CO2 flow meter control range (L)

Flow meter control accuracy

pH meassurement and control range (pH)

DO meassurement and control range (%)

Calibration

SUB500-C-2000L

 

2575

2000

1000

0.4

 

20~90

 

0~50

0~45

0~30

0~15

25~37

Single-use Bags

Volume(L)

Max. Working Volume(L)

Min. Working Volume(L)

Impeller Diameter(mm)

Max. Rotating Speed(RPM)

SUB500-RB-50L

50

50

25

110

150

SUB500-RB-100L

100

100

50

111

150

SUB500-RB-250L

250

250

125

190

150

SUB500-RB-500L

500

500

250

244

120

SUB500-RB-1000L

1000

1000

500

320

90

SUB500-RB-2000L

2000

2000

1000

397

75

Frequently Asked Questions

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